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Temocillin concentrations in human tissues.

J G Gould, G Meikle, D L Cooper

    Drugs
    |January 1, 1985
    PubMed
    Summary
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    Temocillin achieves significant tissue concentrations, particularly in the gallbladder, following intravenous administration before surgery. Higher doses result in increased drug levels in muscle, liver, and skin tissues.

    Area of Science:

    • Pharmacology
    • Surgical Research
    • Antimicrobial Agents

    Background:

    • Temocillin is a penicillinase-resistant penicillin antibiotic.
    • Understanding temocillin tissue penetration is crucial for optimizing surgical prophylaxis and infection treatment.

    Purpose of the Study:

    • To quantify temocillin concentrations in various human tissues.
    • To evaluate the relationship between dosage and tissue drug levels.

    Main Methods:

    • 67 tissue samples from 15 types were collected from 26 patients.
    • Patients received intravenous temocillin (1g or 2g) 3-4 hours before surgery.
    • Serum and tissue concentrations were measured post-administration.

    Main Results:

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  • Mean serum concentrations were 53.5 mg/L (1g) and 117.3 mg/L (2g).
  • Mean tissue concentrations (mg/kg) included muscle (8-10 after 1g, 18 after 2g), liver (8-10 after 1g, 34 after 2g), and skin (8-10 after 1g, 9 after 2g).
  • Gallbladder tissue showed significantly higher temocillin concentrations than other evaluated tissues.

    • Conclusions:

    • Temocillin demonstrates favorable penetration into various surgical tissues.
    • Higher doses of temocillin lead to increased tissue concentrations.
    • The elevated concentrations in gallbladder tissue suggest potential efficacy for biliary tract infections.