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Updated: Jun 13, 2025
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Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.
Published on: May 6, 2010
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Extracting Chromosome Structural Information as One-Dimensional Metrics and Integrating Them with Epigenomics
1School of Biomedical Sciences, Hunan University, Changsha, Hunan, China. wangjk321@hnu.edu.cn.
Methods in Molecular Biology (Clifton, N.J.)
|September 16, 2024
Abstract:
Hi-C is a powerful method for obtaining genome-wide chromosomal structural information. The typical Hi-C analysis utilizes a two-dimensional (2D) contact matrix, which poses challenges for quantitative comparisons, visualizations, and integrations across multiple datasets. Here, we present a protocol for extracting one-dimensional (1D) features from chromosome structure data by HiC1Dmetrics. Leveraging these 1D features enables integrated analysis of Hi-C and epigenomic data.
