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Updated: Jun 13, 2025

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Published on: May 17, 2024
Sweet Spot Regulation of Maternal Metabolic Health and Nutrition on β-Cell Mass in the Offspring
Grace Chung1, Alicia Wong1, Tracy Her1
1Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, MN, USA.
Abstract:
Maternal nutrition and metabolic health status during pregnancy are critical factors that shape the life-long health trajectory of offspring. Altered nutrition during specific times of development in utero can lead to functional changes in tissues such as the pancreatic β-cells, predisposing those tissues to metabolic diseases and Type 2 diabetes that manifest later in life. This chapter will focus on the role of pregnancy complications with altered nutrition during gestation in the maladaptive programming of β-cell mass and function in the offspring.
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