Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Malignant cell transformation and oncogenes].

F L Kiselev

    Genetika
    |June 1, 1985
    PubMed
    Summary

    Retroviruses contain oncogenes crucial for cell transformation. These oncogenes, originating from cellular protooncogenes, can become activated through various genetic alterations, driving cancer development.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Cloning of alternative isoforms of the catalytic subunit of the human thelomerase (htert)].

    Molekuliarnaia genetika, mikrobiologiia i virusologiia·2015
    Same author

    [MicroRNA and cancer].

    Molekuliarnaia biologiia·2015
    Same author

    The regulation of telomerase in oncogenesis.

    Acta naturae·2012
    Same author

    [Telomerase level versus spliced hTERT-specific RNA forms in cervical carcinoma].

    Voprosy onkologii·2010
    Same author

    [Genetic and epigenetic factors of cervical tumor progression].

    Vestnik Rossiiskoi akademii meditsinskikh nauk·2007
    Same author

    [Tumor suppressor gene RBSP3 in cervical carcinoma: copy number and transcriptional level].

    Molekuliarnaia biologiia·2007

    Area of Science:

    • Molecular Biology
    • Oncology
    • Virology

    Context:

    • Retroviruses possess unique genes, oncogenes, essential for cellular malignant transformation.
    • Cellular protooncogenes, the normal counterparts of oncogenes, are present in all cells.
    • Protooncogene activation is a critical step in cancer development.

    Purpose:

    • To investigate the role of oncogenes and protooncogenes in cellular transformation and cancer.
    • To identify the mechanisms of protooncogene activation during malignant conversion.
    • To understand the multistage nature of cancer development.

    Summary:

    • Retroviral oncogenes drive malignant cell transformation.
    • Protooncogenes in normal cells can be activated by mutations, translocations, amplifications, or rearrangements.
    • Transfection techniques have isolated transforming genes from human tumors.
    • Activated oncogenes can trigger other genes, indicating cancer is a multifactorial, multistage process.

    Impact:

    • Elucidates the genetic basis of viral-induced and spontaneous cancers.
    • Provides insights into the molecular mechanisms underlying carcinogenesis.
    • Highlights the potential for targeting oncogene activation in cancer therapy.

    Related Experiment Videos