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iChip

iChip

The cultivation of environmental microorganisms has long been hindered by the inability to replicate complex native conditions in vitro. The isolation chip (iChip) addresses this limitation by facilitating the growth of previously uncultivable microorganisms through in situ incubation. Designed for high-throughput microbial cultivation, the iChip comprises hundreds of microchambers, each capable of housing a single microbial cell. These microchambers are loaded with a mixture of molten agar and...

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Updated: May 4, 2026

Generation of a Human iPSC-Based Blood-Brain Barrier Chip

Generation of a Human iPSC-Based Blood-Brain Barrier Chip

Published on: March 2, 2020

Tissue chips as headway model and incitement technology.

Prerna Suchitan Modi¹, Abhishek Singh¹, Awyang Chaturvedi¹

¹Amity Institute of Biotechnology, Amity University Uttar Pradesh, Noida, Uttar Pradesh, India.

Synthetic and Systems Biotechnology

|September 17, 2024

Summary

This summary is machine-generated.

Organ-on-chip (OOC) technology revolutionizes drug discovery using 3D in-vitro models that mimic human organs. This review explores OOC applications, challenges, and future advancements in scientific research.

Keywords:

2D cell culture 3-Dimensional spheroid 3D cell culture Microfluidic device Organ-on-chip

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Author Spotlight: Advancing the Use of Tissue Chip Technology for Studying Human Tissues

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Area of Science:

Biotechnology
In-vitro modeling
Microfluidics

Background:

Organ-on-chip (OOC) technology utilizes advanced 3D in-vitro cell culture models.
These platforms replicate human organ micro-environments on microfluidic chips.
OOC technology offers an alternative to traditional animal or human testing.

Purpose of the Study:

To provide a comprehensive understanding of organ-on-chip technology.
To detail chip design, instrumentation, and their importance.
To explore diverse applications and future potential of OOC.

Main Methods:

Review of existing literature on organ-on-chip technology.
Analysis of chip design principles and instrumentation requirements.
Examination of OOC applications in various scientific fields.

Main Results:

OOC technology has significant applications in drug discovery, radiobiology, and space research.
The review covers critical aspects of chip design and necessary instrumentation.
Current biological and technical challenges facing OOC technology are identified.

Conclusions:

Organ-on-chip technology is a transformative platform for drug discovery and beyond.
Continued advancements in design and overcoming limitations are crucial for OOC efficacy.
OOC technology holds significant promise for future scientific innovation.