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A 3D-Printed helmet for precise and repeatable neuromodulation targeting in awake non-human primates
Chengjie Tang1, Wenlei Zhang1, Xiaocheng Zhang2
1Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Heliyon
|September 17, 2024
Summary
A novel 3D-printed helmet enables precise non-invasive brain stimulation (NIBS) in awake rhesus monkeys. This advancement improves targeting accuracy for brain research and neurological treatment development.
Area of Science:
- Neuroscience
- Biomedical Engineering
Background:
- Non-invasive brain stimulation (NIBS) in non-human primates (NHPs) is vital for understanding brain networks and developing neurological disease treatments.
- Enhanced precision in NIBS targeting is crucial for improving intervention efficacy.
Purpose of the Study:
- To introduce a 3D-printed helmet for repeatable and precise neuromodulation targeting in awake rhesus monkeys.
- To eliminate the need for head fixation during NIBS procedures in NHPs.
Main Methods:
- Development of a 3D-printed helmet for precise NIBS targeting.
- Utilizing imaging studies to confirm targeting accuracy in the primary motor cortex (M1).
- Conducting stimulation efficacy and physiological evaluations under anesthesia.
Main Results:
- The helmet achieved consistent M1 targeting with sub-millimeter accuracy (<1 mm error).
- Stimulation efficacy evaluations demonstrated high resolution and stability.
- Physiological assessments confirmed successful neuromodulation by generating motor area recruitment curves.
Conclusions:
- The 3D-printed helmet offers a simple, effective method for consistent and precise NIBS targeting in awake NHPs.
- This approach has the potential to advance basic neuroscience research and clinical neuromodulation therapies.
