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Lipid-Laden Floret-Like Multinucleated Giant Cells: A Novel Histopathologic Observation in Rhinophyma.

Maged Daruish1, Rakesh Patalay2, Eduardo Calonje1

  • 1Department of Dermatopathology, St John's Institute of Dermatology, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom ; and.

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|September 17, 2024
PubMed
Summary
This summary is machine-generated.

Rhinophyma, an advanced rosacea stage causing nasal disfigurement, showed unique lipid-containing multinucleated giant cells in 5 of 9 cases. This previously undescribed histopathological finding offers new insights into severe rosacea.

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Area of Science:

  • Dermatology
  • Pathology

Background:

  • Rhinophyma is the advanced stage of rosacea, characterized by nasal disfigurement.
  • Histopathological classifications include classical and severe types.

Purpose of the Study:

  • To investigate the clinicopathological characteristics of rhinophyma.
  • To identify any novel histopathological findings in rhinophyma specimens.

Main Methods:

  • Retrospective analysis of 8 patient cases diagnosed with rhinophyma.
  • Histopathological examination of surgical specimens.

Main Results:

  • Clinicopathological data from 8 rhinophyma cases were analyzed.
  • Floret-like multinucleated giant cells containing lipid were identified in 5 of 9 specimens.
  • This specific cellular finding has not been previously reported in the literature.

Conclusions:

  • The study identified a novel histopathological feature in rhinophyma.
  • The presence of lipid-containing multinucleated giant cells may represent a distinct characteristic of certain rhinophyma cases.