Related Experiment Video

Updated: Jun 12, 2025

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
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In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Published on: October 21, 2022

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Circular RNAs in programmed cell death: Regulation mechanisms and potential clinical applications in cancer: A review

Yudi Gao1, Hong Lin2, Tiantian Tang2

  • 1School of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, 400054, China.

International Journal of Biological Macromolecules
|September 17, 2024
PubMed

Insights

Circular RNAs (circRNAs) regulate programmed cell death (PCD) in tumors. Understanding these interactions offers potential for novel cancer diagnostics and therapeutics.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Circular RNAs (circRNAs) are non-coding RNAs with unique closed structures.
  • circRNAs function as microRNA sponges and interact with RNA-binding proteins.
  • Programmed cell death (PCD) is vital for homeostasis and eliminating compromised cells.

Purpose of the Study:

  • To review the association between circRNAs and PCD in tumor cells.
  • To detail the mechanisms of circRNA-modulated PCD.
  • To highlight circRNAs as potential cancer biomarkers and therapeutic targets.

Main Methods:

  • Comprehensive literature review of circRNAs and PCD in cancer.
  • Analysis of high-throughput sequencing and bioinformatics data.
  • Synthesis of current understanding of molecular mechanisms.

Main Results:

  • circRNAs significantly influence various PCD pathways in cancer.
  • circRNAs can promote or inhibit tumor cell death.
  • Mechanisms involve regulating gene expression and protein interactions.

Conclusions:

  • circRNAs play critical roles in cancer development via PCD modulation.
  • circRNAs hold promise as biomarkers for cancer diagnosis and prognosis.
  • Targeting circRNAs offers a novel therapeutic strategy for cancer treatment.
Keywords:
CancerCircRNAsClinical applicationsProgrammed cell death

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