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Well-Being and Cardiovascular Health: Insights From the UK Biobank Study
Jinghui Zhong1, Pan Zhang1, Yiran Dong1
1Department of Neurology, Division of Life Sciences and Medicine, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC University of Science and Technology of China Hefei Anhui China.
Journal of the American Heart Association
|September 18, 2024
Summary
Higher well-being significantly reduces cardiovascular disease (CVD) risk. This study in UK Biobank data suggests promoting psychological well-being could be key for preventing heart disease.
Area of Science:
- Public Health
- Psychology
- Cardiology
Background:
- Cardiovascular diseases (CVDs) are a major global health issue.
- Growing evidence indicates psychological well-being may protect against CVDs.
Purpose of the Study:
- To investigate the association between well-being and CVD risk.
- To explore potential mediating roles of lifestyle and inflammation.
Main Methods:
- Cohort analysis of 121,317 UK Biobank participants.
- Latent class analysis for well-being categorization.
- Cox models and Mendelian randomization for risk assessment.
Main Results:
- Elevated well-being correlated with substantially lower CVD risk.
- Four well-being groups identified, with higher satisfaction linked to reduced risk.
- Mendelian randomization suggested a potential causal link.
Conclusions:
- A strong inverse relationship exists between well-being and CVD risk.
- Enhancing well-being may serve as a CVD prevention strategy.
- Lifestyle and inflammation partially mediate the well-being-CVD link, offering biological insights.
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