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Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

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Flexible, Electrochemical Skin-Like Platform for Inflammatory Biomarker Monitoring.

Carolina Lourenço^1,2, Felismina Moreira^1,3,4, Rui Igreja²

¹BioMark@ISEP, School of Engineering of Polytechnique School of Porto, Porto, 4200-072, Portugal.

Macromolecular Bioscience

|September 18, 2024

Summary

Researchers developed a novel flexible biosensor using molecularly imprinted polymers (MIPs) for detecting interleukin-6 (IL-6), an inflammatory biomarker. This adaptable skin patch sensor offers a promising advancement in home-based health monitoring and wound management.

Keywords:

Interleukin‐6 biosensor flexible gold transducer molecularly imprinted polymers polyimide substrate

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Fabrication and Characterization of a Conformal Skin-like Electronic System for Quantitative, Cutaneous Wound Management

Fabrication and Characterization of a Conformal Skin-like Electronic System for Quantitative, Cutaneous Wound Management

Published on: September 2, 2015

Area of Science:

Biomedical Engineering
Materials Science
Analytical Chemistry

Background:

Global wound management challenges drive demand for home diagnostic devices.
Skin patch sensors for continuous health monitoring require flexible, biomimetic platforms.

Purpose of the Study:

To develop an innovative, adaptable electrochemical biosensor for detecting the inflammatory biomarker interleukin-6 (IL-6).
To create a flexible platform mimicking human skin for advanced health monitoring.

Main Methods:

Utilized molecularly imprinted polymers (MIPs) on a 3-electrode gold pattern on a polyimide flexible membrane.
Characterized the biosensor using X-ray photoelectron spectroscopy, SEM, and FTIR.
Optimized the biosensing device for sensitivity, selectivity, and reproducibility.

Main Results:

The MIP biosensor demonstrated a linear response from 50 pg/mL to 50 ng/mL for IL-6 detection.
Achieved a low limit of detection of 8 pg/mL.
Confirmed transducer modifications and sensor performance.

Conclusions:

The developed MIP biosensor shows significant potential for sensitive, selective, and reproducible IL-6 detection.
Integration of low-cost electrochemical sensors on flexible polymers enables a new generation of accurate, less invasive patient monitoring tools.
This technology enhances patient comfort and facilitates home-based diagnostics.