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Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...

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The correlation between single and mixed trace elements exposure in systemic lupus erythematosus: A case-control

Rong-Gui Huang1, Kai-Di Li1, Hong Wu1

  • 1Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, Anhui, China.

Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)
|September 18, 2024
PubMed
Summary

Heavy metals like lithium and lead are linked to increased systemic lupus erythematosus (SLE) risk, while selenium shows a protective effect. These trace element associations with SLE require further investigation in larger studies.

Keywords:
Essential trace elementsHeavy metalICP-MSMixed exposurePlasmaSystemic lupus erythematosus

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Area of Science:

  • Environmental Health
  • Immunology
  • Toxicology

Background:

  • Emerging evidence suggests a link between trace elements and systemic lupus erythematosus (SLE).
  • The precise relationship between trace element exposure and SLE pathogenesis remains unclear.
  • This study investigates plasma trace element distribution in newly diagnosed SLE patients.

Purpose of the Study:

  • To determine the distribution of 15 plasma trace elements in SLE patients.
  • To analyze the association between single and mixed trace element exposures and SLE.
  • To explore essential and toxic element interactions in SLE.

Main Methods:

  • Quantification of 15 plasma trace elements using ICP-MS in 110 SLE patients and 110 controls.
  • Application of multivariate logistic regression, RCS, WQS regression, qgcomp, and BKMR.
  • Analysis of associations between individual elements and element mixtures with SLE.

Main Results:

  • Positive correlations found between plasma lithium (Li), vanadium (V), and lead (Pb) and SLE.
  • Negative correlations (protective effects) observed for selenium (Se) and barium (Ba).
  • Non-linear associations identified for Li, V, Ni, copper, Se, and rubidium with SLE; consistent findings for Li, Pb, and Se across multiple models.

Conclusions:

  • Plasma exposure to heavy metals like lithium and lead is significantly associated with increased SLE risk.
  • Selenium (Se) may act as a protective factor against SLE.
  • Non-linear relationships and complex interactions among trace elements in SLE warrant further research.