Dynamics of Thrombogenicity and Platelet Function and Correlation with Bleeding Risk in Patients Undergoing M-TEER...

Area of Science:

• Cardiovascular Medicine
• Interventional Cardiology
• Hematology

Background:

• Transcatheter mitral valve repair (M-TEER) patients face risks of thrombotic and bleeding events.
• The impact of M-TEER on platelet function and its link to bleeding complications remains under-examined.

Purpose of the Study:

• To investigate the association between platelet function parameters, thrombogenicity, and bleeding events following M-TEER.

Main Methods:

• 100 patients undergoing M-TEER were analyzed.
• Platelet function was assessed pre- and post-procedure using impedance aggregometry (Multiplate) and thromboelastography (TEG6s).
• Bleeding complications were tracked for 6 months post-procedure.

Main Results:

• 41 patients experienced bleeding events.
• M-TEER led to decreased ADP aggregation and increased ADP inhibition.
• Platelet function tests, particularly the delta-ADP-Test, showed predictive value for bleeding events, improving risk prediction when combined with clinical factors.

Conclusions:

• Thrombogenicity is altered immediately post-M-TEER, likely due to altered flow dynamics.
• Platelet aggregation via the ADP receptor pathway is significantly linked to post-procedural bleeding.
• Further research is needed to determine if these findings can guide antithrombotic therapy and improve patient outcomes.