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Updated: Jun 12, 2025
Escherichia coli-Based Cell-Free Protein Synthesis: Protocols for a robust, flexible, and accessible platform technology
Published on: February 25, 2019
Recent advances and challenges in single cell protein (SCP) technologies for food and feed production
Yu Pin Li1, Fatemeh Ahmadi2, Khalil Kariman2
1College of Agricultural Resources and Environmental Science, Yunnan Agricultural University, Kunming, 650201, China. liyupin2021@163.com.
Abstract:
The global population is increasing, with a predicted demand for 1250 million tonnes of animal-derived protein by 2050, which will be difficult to meet. Single-cell protein (SCP) offers a sustainable solution. This review covers SCP production mechanisms, microbial and substrate choices, and advancements in metabolic engineering and CRISPR-Cas. It emphasizes second-generation substrates and fermentation for a circular economy. Despite challenges like high nucleic acid content, SCP promises to solve the global nutrition problem.
