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This study developed a bacterial consortium from healthy humans to suppress gut pathobionts. This live bacterial therapy effectively reduced inflammation caused by resistant Enterobacteriaceae in mice.

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Area of Science:

  • Microbiology
  • Immunology
  • Gastroenterology

Background:

  • Long-term antibiotic use or inflammation can lead to pathogenic gut bacteria, causing immune dysregulation and tissue damage.
  • Gram-negative Enterobacteriaceae are difficult to treat with antibiotics and contribute to gut inflammation.
  • Manipulating the gut microbiota is a potential therapeutic strategy for these conditions.

Purpose of the Study:

  • To isolate and select commensal bacterial consortia capable of suppressing intestinal Enterobacteriaceae.
  • To evaluate the efficacy of a specific 18-strain consortium in controlling gut pathobionts and inflammation.

Main Methods:

  • Isolation and selection of commensal bacterial consortia from human stool samples.
  • Administration of an 18-strain consortium to mice with Klebsiella- and Escherichia-induced intestinal inflammation.
  • Assessment of ecological niche control, gluconate availability, colonization resistance, and inflammatory markers.

Main Results:

  • An 18-strain commensal consortium was identified that strongly and specifically suppresses intestinal Enterobacteriaceae.
  • The consortium effectively controlled gut ecological niches by regulating gluconate availability.
  • This led to re-established colonization resistance and alleviated intestinal inflammation in mice.

Conclusions:

  • Live bacterial therapies derived from selected commensal consortia show promise for combating proinflammatory, antimicrobial-resistant Enterobacteriaceae infections.
  • This approach offers a potential alternative to conventional antibiotics for managing gut dysbiosis and associated inflammation.