Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer Survival Analysis01:21

Cancer Survival Analysis

331
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
331
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
Statistical Software for Data Analysis and Clinical Trials01:12

Statistical Software for Data Analysis and Clinical Trials

509
Statistical software is pivotal in data analysis and clinical trials by providing tools to analyze data, draw conclusions, and make predictions. These software packages range from simple data management applications to complex analytical platforms, supporting various statistical tests, models, and simulation techniques. Their significance lies in their ability to handle vast amounts of data with precision and efficiency, enabling researchers to validate hypotheses, identify trends, and make...
509
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

7.3K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
7.3K
What is Cancer?02:12

What is Cancer?

10.6K
Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of...
10.6K
Cancer Vaccines01:30

Cancer Vaccines

345
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
345

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Organocatalytic Multicomponent Reactions Using 1,1-Diaminobenzalazine: Synthesis of Pyrano[2,3-<i>c</i>]pyrazoles and Pyranochromenes.

The Journal of organic chemistry·2026
Same author

Design and Pictet-Spengler enabled synthesis of carboxamide-substituted imidazo[1,2-<i>a</i>]quinoxalines as dual EGFR and tubulin targeting anticancer agents.

Journal of enzyme inhibition and medicinal chemistry·2026
Same author

Cyclopropyl-1,1-Dinitrile as a Five-Atom Synthon: Regioselective Ring-Opening and a Keteneimine-Enamine-Based Nitrile-to-Nitrile Condensation Affording an Entry to Pyridines.

The Journal of organic chemistry·2026
Same author

Correction: Nitrenium ion ↔ nitreone resonance in fused cyclic five-membered triazolium ions (<i>f</i>CFTIs): a quantum chemical study.

Physical chemistry chemical physics : PCCP·2026
Same author

Beyond CRBN and VHL: Parkin driven lysine-based ternary complexes for selective β3-Tubulin degradation.

Computers in biology and medicine·2026
Same author

Graph-Based Classification with GNN-Explainer for Predicting Cardiac Toxicity Associated with Multi-Ion Channel Blockers.

Chemical research in toxicology·2026
Same journal

Integrative analysis of circ_DLGAP4, lncRNA KCNQ1OT1, and the miR-9/SOX7 interaction network in chronic kidney disease progression: a case-control study.

Functional & integrative genomics·2026
Same journal

Multi-omics integration identifies macrophage senescence driven by the RUNX1-P53 axis as a key mechanism in diabetic foot ulcer.

Functional & integrative genomics·2026
Same journal

Positive regulatory role of EuWRKY1 in the biosynthesis of Eucommia ulmoides rubber.

Functional & integrative genomics·2026
Same journal

Environmental enrichment modulates, but does not normalize, aging-associated immune transcriptional programs after ischemic stroke.

Functional & integrative genomics·2026
Same journal

A hypoxia-responsive migrasome-related lncRNA signature predicts prognosis and suggests the MSC-AS1/ITGA5 axis as a potential therapeutic target in head and neck squamous cell carcinoma.

Functional & integrative genomics·2026
Same journal

Genome-wide exploration of biosynthetic gene clusters and their association with virulence in the entomopathogenic fungus Beauveria.

Functional & integrative genomics·2026
See all related articles

Related Experiment Video

Updated: Jun 12, 2025

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
07:41

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases

Published on: May 17, 2019

8.9K

Cancer pharmacoinformatics: Databases and analytical tools.

Pradnya Kamble1, Prinsa R Nagar1, Kaushikkumar A Bhakhar1

  • 1Department of Pharmacoinformatics, National Institute of Pharmaceutical Education and Research, S.A.S. Nagar, Punjab, India.

Functional & Integrative Genomics
|September 18, 2024
PubMed
Summary
This summary is machine-generated.

This review explores cancer big data, highlighting omics technologies and databases. It emphasizes pharmacoinformatics and computational tools for discovering novel cancer therapeutics.

Keywords:
Cancer DatabasesDrug DiscoveryGenomicsImmunologyMetabolomicsPharmacoinformatics

More Related Videos

Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies
07:47

Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies

Published on: September 15, 2023

1.4K
Author Spotlight: Unveiling the Role of TMOD3 in Platinum Resistance and Immune Infiltration in Ovarian Cancer
09:40

Author Spotlight: Unveiling the Role of TMOD3 in Platinum Resistance and Immune Infiltration in Ovarian Cancer

Published on: August 2, 2024

2.6K

Related Experiment Videos

Last Updated: Jun 12, 2025

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
07:41

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases

Published on: May 17, 2019

8.9K
Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies
07:47

Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies

Published on: September 15, 2023

1.4K
Author Spotlight: Unveiling the Role of TMOD3 in Platinum Resistance and Immune Infiltration in Ovarian Cancer
09:40

Author Spotlight: Unveiling the Role of TMOD3 in Platinum Resistance and Immune Infiltration in Ovarian Cancer

Published on: August 2, 2024

2.6K

Area of Science:

  • Oncology
  • Bioinformatics
  • Pharmacology

Background:

  • Cancer research generates vast amounts of big data through omics technologies.
  • Databases are crucial for managing and organizing diverse cancer data, including genomics, proteomics, and immunology.
  • Pharmacoinformatics is an emerging field applying computational tools to rational drug discovery in cancer.

Purpose of the Study:

  • To catalog databases and computational tools relevant to cancer drug discovery.
  • To highlight the role of these resources in the pharmacoinformatics of cancer.
  • To discuss the integration of computational approaches for identifying novel therapeutic molecules.

Main Methods:

  • Review and compilation of existing cancer-related databases.
  • Identification and categorization of computational tools used in cancer research.
  • Analysis of the application of statistical approaches and artificial intelligence/machine learning in pharmacoinformatics.

Main Results:

  • Numerous databases exist across genomics, transcriptomics, proteomics, metabolomics, immunology, and drug discovery.
  • Pharmacoinformatics integrates structure modeling, database analysis, and AI/ML for drug discovery.
  • Software tools are essential for oncoinformatics research and cancer drug development.

Conclusions:

  • Effective management and analysis of cancer big data are vital for advancing drug discovery.
  • Pharmacoinformatics, utilizing databases and computational tools, plays a pivotal role in identifying novel cancer therapeutics.
  • This review provides a catalog of resources to aid researchers in cancer drug discovery and pharmacoinformatics.