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Summary

Hemosorption improves donor blood storage, preservation, and transfusion, enhancing effectiveness in critical care. This technique optimizes blood parameters and reduces harmful substances for better patient outcomes.

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Area of Science:

Biomedical Engineering
Transfusion Medicine
Blood Preservation

Background:

Donor blood storage and transfusion face challenges in maintaining optimal blood parameters.
Current methods may not adequately address metabolic byproducts or cellular integrity.
Specific patient populations, like those with renal or liver insufficiency, require enhanced blood products.

Purpose of the Study:

To evaluate the effectiveness of hemosorption in improving donor blood quality for storage, preservation, and transfusion.
To assess the impact of hemosorption on key blood parameters and cellular components.
To determine the benefits of hemosorption in clinical applications such as massive or exchange transfusions.

Main Methods:

Application of the hemosorption technique to donor blood.
Analysis of blood parameters including erythrocyte metabolism, electrolyte balance, and pH.
Quantification of harmful metabolic products, microclots, and impaired cells.
Measurement of erythrocyte osmotic resistance, blood viscosity, and HBS-antigen levels.

Main Results:

Hemosorption significantly enhances the effectiveness of blood storage, preservation, and transfusion.
Correction of erythrocyte metabolism, intra-/extracellular electrolyte supply, and blood pH towards normal levels.
Reduction in harmful metabolic products, microclots, and impaired cells.
Significant increase in erythrocyte osmotic resistance; decrease in blood viscosity and HBS-antigen levels.

Conclusions:

Hemosorption offers a substantial improvement in donor blood quality and transfusion efficacy.
The technique is particularly beneficial for massive/exchange transfusions and in patients with renal or liver insufficiency.
Hemosorption optimizes blood's physiological properties and reduces transfusion-related risks.

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