Related Experiment Video
Updated: Jun 12, 2025

Spatial Separation of Molecular Conformers and Clusters
Published on: January 9, 2014
Spontaneous separation of attractive chiral mixtures
Jia-Jian Li1, Rui-Xue Guo1, Bao-Quan Ai1
1Key Laboratory of Atomic and Subatomic Structure and Quantum Control (Ministry of Education), Guangdong Basic Research Center of Excellence for Structure and Fundamental Interactions of Matter, School of Physics, <a href="https://ror.org/01kq0pv72">South China Normal University</a>, Guangzhou 510006, China and Guangdong Provincial Key Laboratory of Quantum Engineering and Quantum Materials, and Guangdong-Hong Kong Joint Laboratory of Quantum Matter, <a href="https://ror.org/01kq0pv72">South China Normal University</a>, Guangzhou 510006, China.
Abstract:
The separation of chiral matter has garnered significant attention due to its wide-ranging applications in biological and chemical processes. In prior researches, particle interactions were predominantly repulsive, but the indiscriminate attraction among particles under attractive interactions makes the separation of mixtures more difficult. The question of whether chiral mixed particles, characterized by attractive effects, can undergo spontaneous separation, remains unresolved. We study a binary mixture of chiral (counterclockwise or clockwise) active particles with attractive interactions. It is demonstrated that attractive chiral particles can undergo spontaneous separation without the aid of any specific strategies. The key factor driving the separation is the attractive interactions, enabling the formation of stable clusters of particles with same chirality. There exist optimal parameters (self-propelled velocity, angular velocity, and packing fraction) at which the separation is optimal. Our results may contribute to a deeper understanding of the mechanisms behind chiral matter separation and potentially catalyze further experimental investigations in this field.
Related Concept Videos
Racemic Mixtures and the Resolution of Enantiomers
Prochirality
Molecules with Multiple Chiral Centers
Properties of Enantiomers and Optical Activity
SN1 Reaction: Stereochemistry
In the first step of an SN1 reaction, the bond between the electrophilic carbon and the leaving group ionizes to generate the carbocation intermediate. The second step of the mechanism is the nucleophilic attack.
In the formed carbocation, the positively charged carbon is sp2 hybridized with a trigonal planar geometry. As all the three substituents lie on the same plane, a plane of symmetry for the...
Chirality in Nature

