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Relationship between functional status and fatigue after COVID-19 infection: a multicenter study from Türkiye
İpek Candemir1, Pınar Ergün1, Dicle Kaymaz1
1Department of Chest Diseases, Ankara Atatürk Sanatoryum Education and Research Hospital, University of Health Sciences, Ankara, Turkiye.
Turkish Journal of Medical Sciences
|September 19, 2024
Summary
Persistent fatigue after COVID-19 significantly impacts functional status, independent of recovery time. Addressing modifiable risk factors and infection severity is crucial for improving long-term outcomes in COVID-19 survivors.
Area of Science:
- Medical Research
- Infectious Diseases
- Pulmonology
Background:
- COVID-19 can lead to persistent symptoms, including fatigue, impacting patients' functional status long after infection.
- The interplay between fatigue, functional status, and other patient factors post-COVID-19 requires further investigation.
Purpose of the Study:
- To investigate the relationship between fatigue and functional status in patients recovering from COVID-19.
- To identify factors associated with fatigue and reduced functional status in the post-COVID-19 period.
Main Methods:
- A multicenter, cross-sectional study enrolled 1095 COVID-19 patients.
- Data collected included demographics, comorbidities, COVID-19 severity markers, and validated questionnaires (PCFS, FSS, EQ-5D-5L).
Main Results:
- A positive correlation was found between Post-COVID Functional Status (PCFS) and Fatigue Severity Scale (FSS) scores (r = 0.49).
- Both fatigue and functional status were linked to quality of life.
- Factors associated with poorer outcomes included older age, higher BMI, systemic disease, lack of exercise, and severe COVID-19 infection.
Conclusions:
- Fatigue is a significant determinant of functional status in COVID-19 survivors, irrespective of time since diagnosis.
- Patients with FSS scores above 4.78 experienced moderate to severe functional limitations.
- Addressing modifiable patient risk factors and mitigating COVID-19 severity are essential for recovery.
