Related Experiment Video

Updated: Jun 12, 2025

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

178

The role of long non-coding RNA NORAD in digestive system tumors

Yussel Pérez-Navarro1, Yarely M Salinas-Vera2, Cesar López-Camarillo3

  • 1Posgrado en Ciencias Genómicas, Laboratorio de Patogénesis Celular y Molecular Humana y Veterinaria, Universidad Autónoma de la Ciudad de México, Ciudad de México, CDMX, Mexico.

Non-Coding RNA Research
|September 19, 2024
PubMed

Insights

Long non-coding RNA NORAD is frequently upregulated in digestive cancers, promoting tumor progression. Understanding its role as a competitive endogenous RNA offers potential therapeutic targets for colorectal, pancreatic, and gastric cancers.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Long non-coding RNAs (lncRNAs) are increasingly recognized for their roles in cancer development.
  • NORAD (DNA damage-activated lncRNA) is frequently overexpressed in digestive system tumors, including colorectal, pancreatic, and gastric cancers.

Purpose of the Study:

  • To review the functions of NORAD in digestive system cancers.
  • To emphasize NORAD's involvement in key cellular processes like invasion, metastasis, proliferation, and apoptosis.
  • To explore NORAD's potential as a therapeutic target.

Main Methods:

  • Literature review of studies investigating NORAD in digestive cancers.
  • Analysis of NORAD's molecular mechanisms, including its function as a competing endogenous RNA (ceRNA).
  • Consolidation of current knowledge on NORAD's impact on tumorigenesis.

Main Results:

  • NORAD acts as a ceRNA, sponging microRNAs to regulate target gene expression involved in cancer.
  • Its dysregulation is linked to critical cancer hallmarks such as invasion, metastasis, proliferation, and apoptosis.
  • NORAD influences multiple signaling pathways implicated in digestive cancer progression.

Conclusions:

  • NORAD plays a significant role in the development and progression of digestive system cancers.
  • Further research into NORAD's complex functions is crucial for developing novel therapeutic strategies.
  • Targeting NORAD presents a promising avenue for innovative cancer treatments.
Keywords:
ApoptosisCancerNORADProliferationlncRNAs

More Related Videos

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR13:04

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR

Published on: March 1, 2019

8.8K
Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos07:24

Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos

Published on: December 13, 2018

6.4K

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.5K
Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
11.4K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.8K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.0K
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.1K