Cyclodextrin-Based Nanogels for Stabilization and Sensing of Curcumin

Curcumin (CUR), a polyphenolic substance from turmeric, displays diverse medicinal properties. However, its instability poses challenges in detection. Cyclodextrin-based nanogels (CyDngs) offer a transformative solution, enhancing CUR's stability in aqueous solutions. Multisensing approaches involving fluorescence, electrochemistry, and NMR spectroscopy were employed, demonstrating CyDngs' pivotal role in CUR detection. Langmuir analysis revealed a binding constant of 1.4 × 10⁴ M^-1 for CyDngs, highlighting their effectiveness over native β-CyDs. The study emphasized CyDngs' superiority in stabilizing CUR and enabling reliable and sensitive detection with very diverse methods.