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Cyclodextrin-Based Nanogels for Stabilization and Sensing of Curcumin.

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Cyclodextrin-based nanogels (CyDngs) significantly enhance curcumin (CUR) stability and detection. This study demonstrates CyDngs

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Area of Science:

  • Nanotechnology
  • Analytical Chemistry
  • Biochemistry

Background:

  • Curcumin (CUR), a turmeric-derived polyphenol, possesses various medicinal properties.
  • CUR's inherent instability in aqueous solutions complicates its detection and application.
  • Cyclodextrin-based nanogels (CyDngs) present a novel approach to stabilize CUR.

Purpose of the Study:

  • To evaluate the efficacy of CyDngs in enhancing the stability of CUR.
  • To develop and validate multisensing methods for sensitive CUR detection using CyDngs.
  • To compare the performance of CyDngs with native beta-cyclodextrins (β-CyDs) for CUR stabilization and detection.

Main Methods:

  • Preparation and characterization of cyclodextrin-based nanogels (CyDngs).
  • Multisensing techniques including fluorescence, electrochemistry, and Nuclear Magnetic Resonance (NMR) spectroscopy.
  • Langmuir adsorption isotherm analysis to determine binding constants.

Main Results:

  • CyDngs significantly improved CUR's stability in aqueous solutions.
  • Successful detection of CUR using fluorescence, electrochemistry, and NMR spectroscopy facilitated by CyDngs.
  • Langmuir analysis yielded a binding constant of 1.4 × 104 M-1 for CyDngs, indicating strong CUR binding.

Conclusions:

  • CyDngs are superior to native β-CyDs in stabilizing CUR.
  • The developed CyDng-based multisensing platform enables reliable and sensitive CUR detection.
  • This approach holds promise for advancing CUR-based diagnostics and therapeutics.