Synthesis of Pt-MoS₂ with enhanced photothermal and peroxidase-like properties and its antibacterial application

Despite tremendous efforts, bacterial infection and contamination remain a major clinical challenge to modern humans. Nanozyme materials with stimuli-responsive properties are expected to be powerful tools for the next generation of antibacterial therapy. Here, MoS₂ nanosheet was firstly prepared by liquid phase exfoliation method, and Pt-MoS₂ hybrid biomaterial was then successfully synthesized by a simple self-reduction method. The Pt decoration significantly improves the photothermal effect of MoS₂ nanosheet under 808 nm NIR laser irradiation. Besides, benefiting from the formation of heterogeneous structure, the Pt-MoS₂ has significantly enhanced peroxidase mimetic catalytic activity, which can kill bacteria through catalysis of H₂O₂ to generate antimicrobial hydroxyl radicals. Moreover, the temperature rise brought about by NIR laser stimulation further amplifies the nanozyme activity of the composites. After treatment by the synergistic platform, both Staphylococcus aureus and Escherichia coli can be effectively inhibited, demonstrating its broad-spectrum antibacterial properties. In addition, the developed antibacterial Pt-MoS₂ nanozyme have the excellent biocompatibility, which makes them well suited for infection elimination in biological systems. Overall, this work shows great potential for rationally combining the multiple functions of MoS₂-based nanomaterials for synergistic antibacterial therapy. In the future, the Pt-MoS₂ nanozyme may find wider applications in areas such as personal healthcare or surface disinfection treatment of medical devices.