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Updated: Jun 12, 2025
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A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
Published on: September 30, 2021
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Exploring Hepatocellular Carcinoma Pathogenesis: The Influence of Genetic Polymorphisms
Samaneh Mollazadeh1, Nikoo Saeedi2, Abdulridha Mohammed Al-Asady3
1Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran.
Current Pharmaceutical Design
|September 19, 2024
Summary
Genetic variations, known as polymorphisms, significantly impact hepatocellular carcinoma (HCC) development and progression. Understanding these genetic factors is crucial for identifying new therapeutic targets in HCC.
Area of Science:
- Oncology
- Genetics
- Molecular Biology
Background:
- Hepatocellular carcinoma (HCC) development is multifactorial, with genetic polymorphisms significantly influencing disease risk and outcomes.
- Specific gene variations affect critical molecular pathways implicated in HCC, including cellular metabolism, inflammation, proliferation, and apoptosis.
Purpose of the Study:
- To review the multifaceted roles of genetic polymorphisms in hepatocellular carcinoma (HCC) pathogenesis.
- To elucidate the complex interactions between genetic variations and HCC development, progression, and treatment response.
Main Methods:
- Comprehensive literature review of studies investigating genetic polymorphisms associated with HCC.
- Analysis of how polymorphisms in key genes impact HCC-related biological pathways.
Main Results:
- Genetic polymorphisms demonstrate varied effects on an individual's susceptibility to HCC.
- These variations influence HCC disease progression and response to therapeutic interventions.
- Polymorphisms affect pathways regulating inflammation, cell growth, and programmed cell death in HCC.
Conclusions:
- Genetic polymorphisms are pivotal in HCC pathogenesis, influencing susceptibility, progression, and treatment outcomes.
- Further research into these genetic variations can reveal underlying mechanisms and potential therapeutic strategies for HCC.
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