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The Use of Tranexamic Acid and Microneedling in the Treatment of Melasma: A Systematic Review
Idowu D Olugbade1, Nicole A Negbenebor1
1Idowu D. Olugbade is from the Warren Alpert Medical School of Brown University, Providence, Rhode Island. Dr. Negbenebor is from the Department of Dermatology, University of Iowa, Iowa City.
Abstract:
Melasma is a chronic pigmentary disorder that results in hyperpigmented patches in sun-exposed areas. Tranexamic acid (TXA) and microneedling are potential treatment options for individuals with melasma. The objective of our systematic review was to review 12 randomized controlled trials and clinical trials on the use and efficacy of TXA with microneedling for melasma. The combination of TXA and microneedling was found to be more effective at improving melasma lesions than either treatment alone; TXA alone was equally effective at reducing melasma lesions vs the standard treatment of hydroquinone.

