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Xueqi Wang¹, Yuzhuo Zhu², Zhaoming Cheng¹

¹College of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, PR China; State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, PR China; Tianjin Key Laboratory of Intelligent and Green Pharmaceuticals for Traditional Chinese Medicine, Tianjin 301617, PR China; State Key Laboratory of Chinese Medicine Modernization, Tianjin 301617, PR China.

Acta Biomaterialia

|September 19, 2024

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Summary

Microfluidic gut-on-a-chip (GOC) systems offer advanced in vitro models for studying drug absorption. These novel platforms overcome limitations of traditional models, providing better insights for drug development.

Area of Science:

Biomedical Engineering
Gastroenterology
Pharmacology

Background:

Traditional gut models fail to replicate the complex gastrointestinal microenvironment for drug absorption studies.
Organ-on-a-chip technologies offer a promising alternative for in vitro gut modeling.
Microfluidic gut-on-a-chip (GOC) systems are emerging as powerful tools for biomedical research.

Purpose of the Study:

To review recent advancements in microfluidic GOC systems for reconstructing gut structure and function.
To discuss the applications of GOC platforms in drug development, including disease modeling.
To highlight the potential, challenges, and future directions of GOC technology in pharmaceutical research.

Main Methods:

Overview of cell types used in GOC model construction.

Keywords:

Drug development Gut Intestine Microfluidic system Organ-on-a-chip

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Discussion of microfluidic devices for drug absorption studies.

Systematic review of gut-related multichip coupling and disease modeling applications.

Main Results:

GOC systems provide cost-effective, ethically sound alternatives to animal models.
These platforms offer enhanced ability to study inter-species differences in drug metabolism.
GOC technology yields novel insights into gut structure, disease mechanisms, and drug absorption.

Conclusions:

Microfluidic GOC systems represent a significant advancement in in vitro gut modeling for drug development.
These platforms facilitate innovative design and application for studying drug absorption and disease.
Further development of GOC technology promises to accelerate biomedical research and drug discovery.