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Related Experiment Video

Updated: Jun 12, 2025

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy

Published on: February 21, 2025

Sarcopenia.

Avan A Sayer^1,2, Rachel Cooper^3,4, Hidenori Arai⁵

¹AGE Research Group, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK. avan.sayer@newcastle.ac.uk.

Nature Reviews. Disease Primers

|September 19, 2024

Summary

This summary is machine-generated.

Sarcopenia, the age-related loss of muscle mass and function, affects 5-10% of the population. New diagnostic approaches emphasize muscle strength, with resistance exercise as a primary treatment.

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Human Vastus Lateralis Skeletal Muscle Biopsy Using the Weil-Blakesley Conchotome

Human Vastus Lateralis Skeletal Muscle Biopsy Using the Weil-Blakesley Conchotome

Published on: March 4, 2016

Area of Science:

Gerontology
Muscle Physiology
Aging Research

Background:

Sarcopenia is the accelerated loss of skeletal muscle mass and function, primarily associated with aging.
It impacts physical function, mobility, and increases risks of falls, fractures, and mortality.
Prevalence ranges from 5-10% in the general population, with varying definitions.

Purpose of the Study:

To explore a life course framework for understanding sarcopenia development and prevention.
To review sarcopenia pathophysiology in light of aging hallmarks.
To discuss the evolving diagnostic approaches and treatment strategies for sarcopenia.

Main Methods:

Literature review on sarcopenia definition, diagnosis, and treatment.
Analysis of the role of aging hallmarks in sarcopenia.
Discussion of a life course perspective on sarcopenia.

Main Results:

Growing consensus on diagnosing sarcopenia, with increased focus on muscle strength.
Resistance exercise is the primary treatment, but not universally suitable.
A life course framework offers insights into prevention.

Conclusions:

An internationally agreed definition and diagnostic approach for sarcopenia is anticipated.
Adjunctive and alternative treatments are needed to improve quality of life.
Understanding sarcopenia across the life course is crucial for effective prevention and management.