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Intracranial Pharmacotherapy and Pain Assays in Rodents
Published on: April 9, 2019
Effectiveness of tramadol-including multimodal analgesia in spinal surgery: a single-center, retrospective cohort
Misa Okizuka1, Ryo Inose2, Satoshi Makio3
1Department of Pharmacy, Rakuwakai Marutamachi Hospital, 9-7 Matsushita-Cho, Kyoto, Jurakumawari, Nakagyo-ku, Kyoto-shi, 604-8401, Japan.
Background:
Multimodal analgesia (MMA) is recommended for postoperative pain management; however, studies evaluating the effect of tramadol-including MMA on numerical rating scale (NRS)-based postoperative pain levels and the length of stay (LOS) in the hospital are limited. Therefore, this study aimed to compare the before and after effects of tramadol-including MMA application, and assess its effect on postoperative NRS scores and LOS.
Methods:
Patients who underwent spinal surgery under general anesthesia at the Rakuwakai Marutamachi Hospital in fiscal years 2020 and 2022 were included in this study. The outcomes between the pre- and post-intervention groups were compared through propensity score matching.
Results:
Following propensity score matching, 249 patients were included in each group. MMA application significantly decreased the median LOS from 10 to 9 days (p < 0.001). Additionally, the median NRS scores exhibited a significant decrease from 4 to 3 on postoperative day (POD) 3 (p = 0.0109) and from 3 to 2 on POD 5 (p = 0.0087). Following MMA application, the number of patients receiving additional analgesics decreased significantly, from 38 to 6 (p < 0.001).
Conclusions:
The introduction of tramadol-including MMA can effectively reduce postoperative pain and decrease the LOS for patients undergoing spinal surgery.
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