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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

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A Novel Hybrid Injectable for Soft-tissue Augmentation: Analysis of Data and Practical Experience.

André Braz¹, Camila Cazerta de Paula Eduardo², Alexander Pierce³

¹From Private Practice, Rio de Janeiro, Brazil.

Plastic and Reconstructive Surgery. Global Open

|September 20, 2024

Summary

HArmonyCa, a hybrid injectable filler combining hyaluronic acid and calcium hydroxyapatite, offers immediate volume restoration and stimulates collagen for improved skin quality. Clinical data confirm its safety, efficacy, and high patient satisfaction in aesthetic treatments.

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Area of Science:

Aesthetic Medicine
Dermatology
Biomaterials Science

Background:

HArmonyCa is a novel hybrid injectable filler composed of hyaluronic acid (HA) gel and calcium hydroxyapatite (CaHa) microspheres.
This product is designed for aesthetic applications, aiming to provide both immediate volume and long-term skin quality improvement.

Purpose of the Study:

To review preclinical and clinical data on the hybrid injectable filler HArmonyCa.
To provide recommendations for product use based on clinical experience and illustrate outcomes through case studies.

Main Methods:

Extraction of preclinical and clinical data from various sources including literature, manufacturer data, and proprietary files.
Presentation of case studies based on the primary author's clinical experience with the HArmonyCa filler.

Main Results:

Preclinical studies showed HArmonyCa has superior lift capacity and faster tissue integration compared to CaHa fillers, stimulating collagen production.
Clinical studies demonstrated safety, effectiveness, and high patient satisfaction, with injection-site response being the most common adverse event.

Conclusions:

The hybrid HA/CaHa injectable filler offers immediate volume restoration and potential for improved skin architecture and soft-tissue quality over time.
Clinician recommendations are provided for optimal aesthetic results and adverse event mitigation.