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Laryngopharyngeal Reflux Pathophysiology, Clinical Presentation, and Management: A Narrative Review
William T Barham1, Alana V Alvarez-Amado2, Kathryn M Dillman1
1School of Medicine, Louisiana State University Health Sciences Center, New Orleans, USA.
Cureus
|September 20, 2024
Summary
Laryngopharyngeal reflux (LPR) causes upper aerodigestive tract symptoms. This review clarifies LPR pathophysiology, diagnosis, and management for better patient care.
Area of Science:
- Otolaryngology
- Gastroenterology
- Digestive System Diseases
Background:
- Laryngopharyngeal reflux (LPR) is a prevalent condition often misdiagnosed.
- It involves gastric content reflux irritating the upper aerodigestive tract.
- LPR significantly impacts patient morbidity.
Purpose of the Study:
- To review the pathophysiology, symptoms, and management of LPR.
- To emphasize the role of gastric reflux in aerodigestive tissue irritation.
- To unify existing research on LPR for improved clinical recognition and treatment.
Main Methods:
- Narrative literature review.
- Analysis of evidence-based findings from RCTs, clinical studies, and meta-analyses.
- Review of anatomical structures, pathogenic mechanisms, endoscopic findings, and clinical manifestations.
Main Results:
- LPR pathophysiology, symptoms, and management were reviewed.
- The review covers anatomical basis, pathogenic mechanisms, and clinical presentations.
- Current controversies and emerging diagnostic tools were discussed.
Conclusions:
- Accurate understanding of LPR pathophysiology aids diagnosis and treatment.
- Emerging research on cellular damage and diagnostics may improve LPR characterization.
- Future research aims to unify LPR management guidelines for primary care and specialists.
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