Fe(III)-catalyzed p-selective C-H bond chalcogenation of phenols
Biprajit Paul1, Sayak Ghosh1, Surajit Das1
1Department of Chemistry, Indian Institute of Technology Ropar, Nangal Road, Rupnagar, Punjab-140001, India. indranil.chatterjee@iitrpr.ac.in.
Abstract:
An efficient, eco-friendly, and scalable protocol has been introduced for the p-selective C-X (X = Se/S) bond formation of phenols employing earth-abundant, less-toxic Fe(III)-catalysts and the green solvent ethanol without using any directing template, stabilizing ligands, oxidants, or additives. The key attraction lies in the impressive p-selectivity with moderate to good yields, wide functional group compatibility under mild aerobic reaction conditions, and the synthetic modification of the products towards value-added molecules.
More Related Videos
06:46Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
06:34Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides CHIPS
Published on: June 20, 2014
Related Concept Videos
Electrophilic Addition to Alkynes: Hydrohalogenation
Regioselectivity of Electrophilic Additions-Peroxide Effect
Electrophilic 1,2- and 1,4-Addition of X2 to 1,3-Butadiene
Benzene to Phenol via Cumene: Hock Process
[3,3] Sigmatropic Rearrangement of Allyl Vinyl Ethers: Claisen Rearrangement
Acid Halides to Esters: Alcoholysis
![Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-phosphinetriyltripiperidine]}palladium Under Mild Reaction Conditions](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F51444.jpg&w=3840&q=50)