Related Experiment Video
Updated: Jun 12, 2025
07:29
Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
9.3K
Dyslipidemia and lower extremity arterial disease
Kosmas I Paraskevas1, Pavel Poredos2, Agata Stanek3
1Department of Vascular Surgery, Red Cross Hospital, Athens, Greece - paraskevask@hotmail.com.
International Angiology : a Journal of the International Union of Angiology
|September 20, 2024
Summary
Dyslipidemia significantly contributes to lower extremity arterial disease (LEAD) development. Intensive lipid-lowering treatment is crucial for managing LEAD symptoms, preventing amputations, and reducing overall cardiovascular events.
Area of Science:
- Vascular Medicine
- Cardiovascular Research
- Lipid Metabolism
Background:
- Dyslipidemia is a recognized risk factor for cardiovascular diseases.
- Lower extremity arterial disease (LEAD) is a manifestation of systemic atherosclerosis.
Purpose of the Study:
- To review the role of dyslipidemias in the pathogenesis of LEAD.
- To evaluate the impact of lipid-lowering therapy on LEAD progression.
Main Methods:
- Comprehensive literature search of PubMed/MedLine, EMBASE, and Scopus databases.
- Inclusion of studies from January 1990 to January 2024.
- Focused searches on dyslipidemia's role in LEAD and effects of lipid-lowering treatments.
Main Results:
- Strong evidence links dyslipidemias to the development of LEAD.
- Intensive lipid-lowering therapy is recommended for all LEAD patients.
- Therapy reduces claudication, amputation rates, myocardial infarction, and cardiovascular events.
Conclusions:
- Dyslipidemia plays a critical role in the pathogenesis and progression of LEAD.
- Vascular specialists must consider dyslipidemia management in LEAD patients.
More Related Videos
Related Concept Videos
01:29Cholesterol: Significance and Regulation
519
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
519
01:20Lipid-Lowering Drugs: Statins and Miscellaneous Agents
584
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
584
01:25Blood Studies for Cardiovascular System III: Serum Lipid Profile
135
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
135
01:27Assessment of the Cardiovascular System III: Palpation
214
Palpation involves feeling the body to evaluate texture, size, consistency, and tenderness for assessing cardiovascular health. The following steps are organized in a head-to-toe order:
Jugular Venous Pressure (JVP) Measurement
Position the patient at a thirty- to forty-five-degree angle or in a semi-fowler's position. Look for the highest point of pulsation in the internal jugular vein and measure the vertical distance to the angle of Loius or sternal angle. A normal JVP is 3-4 cm above...
Jugular Venous Pressure (JVP) Measurement
Position the patient at a thirty- to forty-five-degree angle or in a semi-fowler's position. Look for the highest point of pulsation in the internal jugular vein and measure the vertical distance to the angle of Loius or sternal angle. A normal JVP is 3-4 cm above...
214
01:24Overview of Lipid Metabolism
1.1K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
1.1K
01:20Arteries of Lower Limbs
1.3K
The external iliac artery transitions out of the body cavity, entering the femoral region of the lower leg, and is renamed the femoral artery at the point where it traverses the body wall. This artery is responsible for the distribution of blood to the thigh's deep muscles and the skin's ventral and lateral regions, achieved through several minor branches and the lateral deep femoral artery, which also spawns a lateral circumflex artery. The knee area receives blood from the genicular...
1.3K