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Past, Present, and Future of Liver-Brain Axis in Alzheimer's Disease: A Bibliometric Review
Xin Lian Liu1, Jianishaya Yeerlan2, Zhirong Liu3
1Development and Regeneration Key Laboratory of Sichuan Province, Department of Pathology and Pathophysiology, Institute of Neuroscience, Chengdu Medical College, Chengdu, China.
Background:
No effective drugs currently exist to cure Alzheimer's disease (AD) due to its complexity and the lack of understanding of the involved molecular signaling and pathways. The relationship between liver health and AD is now widely recognized. Still, molecular links and shared pathways between the liver and brain remain unclear, making the liver-brain axis in AD therapies a new area for exploration. However, bibliometric studies on this topic are lacking.
Objective:
This study aims to review the liver-brain axis in AD and identify future research hotspots and trends through bibliometric analysis.
Methods:
Articles and reviews related to AD and liver and its related diseases were searched in the Web of Science Core Collection (WoSCC) database up to 2024. Data were processed and visually analyzed using VOSviewer, CiteSpace, and Pajek.
Results:
We collected 1,777 articles on AD and liver and its related diseases from 2,517 institutions across 80 countries. Keyword cluster analysis identified 11 clusters, with 'insulin resistance,' 'amyloid-beta,' 'apolipoprotein-E,' 'oxidative stress,' and 'inflammation' appearing most frequently, and exhibiting strong total link strength. These results indicate that these topics have been the primary focus of research on the liver-brain axis in AD.
Conclusions:
This study is the first to comprehensively analyze the liver-brain axis in AD using bibliometric methods. The research results identify recent research frontiers and hotspots, aiding scholars in gaining a deeper understanding of the correlation between AD and the liver.
Insights
This bibliometric study reveals key research trends in the liver-brain axis for Alzheimer's disease (AD). It highlights insulin resistance, amyloid-beta, and inflammation as central themes in understanding AD and liver health connections.
Area of Science:
- Neuroscience
- Hepatology
- Bibliometrics
Background:
- Alzheimer's disease (AD) lacks effective cures due to complex molecular pathways.
- The liver-brain axis is increasingly recognized as relevant to AD pathogenesis.
- Molecular links and shared pathways between the liver and brain in AD remain poorly understood.
Purpose of the Study:
- To conduct a bibliometric analysis of research on the liver-brain axis in Alzheimer's disease.
- To identify emerging research hotspots and future trends in this interdisciplinary field.
Main Methods:
- A comprehensive search of the Web of Science Core Collection database was performed for articles and reviews up to 2024.
- Bibliometric analysis was conducted using VOSviewer, CiteSpace, and Pajek software.
- Keyword cluster analysis was employed to identify prominent research themes.
Main Results:
- 1,777 articles were analyzed, originating from 2,517 institutions across 80 countries.
- Eleven keyword clusters were identified, with 'insulin resistance,' 'amyloid-beta,' 'apolipoprotein-E,' 'oxidative stress,' and 'inflammation' being the most frequent and strongly linked.
- These keywords represent the core research focus on the liver-brain axis in AD.
Conclusions:
- This study provides the first comprehensive bibliometric overview of the liver-brain axis in Alzheimer's disease.
- The findings illuminate current research frontiers and key areas of investigation.
- This analysis aids researchers in understanding the intricate relationship between liver health and AD.
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