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Updated: Jun 12, 2025
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Probiotic Studies in Neonatal Mice Using Gavage
Published on: January 27, 2019
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Microbial colonization programs are structured by breastfeeding and guide healthy respiratory development
Liat Shenhav1, Kelsey Fehr2, Myrtha E Reyna3
1Institute for Systems Genetics, New York Grossman School of Medicine, New York University, New York, NY, USA; Department of Microbiology, New York Grossman School of Medicine, New York University, New York, NY, USA; Department of Computer Science, Courant Institute of Mathematical Sciences, New York University, New York, NY, USA.
Cell
|September 20, 2024
Summary
Extended breastfeeding promotes healthy infant microbial development, reducing the risk of preschool asthma. Early cessation disrupts this crucial window, increasing asthma risk through altered gut bacteria and functions.
Area of Science:
- Microbiome research
- Infant immunology
- Respiratory health
Background:
- Breastfeeding and infant microbial colonization are critical for immune development and respiratory health.
- Mechanisms of breastfeeding's protective effects and microbial regulation remain unclear.
Purpose of the Study:
- To investigate the relationship between breastfeeding, infant microbiomes, and preschool asthma.
- To identify microbial and milk components mediating breastfeeding's protective effects.
Main Methods:
- Profiling nasal and gut microbiomes in 2,227 children from the CHILD Cohort Study.
- Analyzing breastfeeding characteristics and maternal milk composition.
- Correlating microbiome patterns and milk components with asthma risk.
Main Results:
- Identified colonization patterns and milk components that predict preschool asthma.
- Early breastfeeding cessation (before 3 months) linked to premature microbial acquisition (e.g., Ruminococcus gnavus, tryptophan biosynthesis).
- Longer exclusive breastfeeding associated with paced microbial development and protection against asthma.
Conclusions:
- Extended breastfeeding is crucial for infant respiratory health.
- Microbial colonization patterns and specific milk components play a key role in asthma development.
- Targeting microbial pathways may offer new interventions for preventing childhood asthma.
Keywords:
asthmabreastfeedingcomputational biologydevelopmentearly lifegut microbiomehuman milkmachine learningmicrobial dynamicsmicrobiome developmentnasal microbiomerespiratory healthMore Related Videos
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