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Current Insights on Lipidomics in Dermatology: A Systematic Review
Raquel Sanabria-de la Torre1, Trinidad Montero-Vílchez2, Juan García-Gavín3
1Biosanitary Research Institute of Granada (ibs.GRANADA), Granada, Spain; Department of Biochemistry and Molecular Biology III and Immunology, University of Granada, Granada, Spain; Dermatology Department, Virgen de las Nieves University Hospital, Granada, Spain.
Skin lipidomics reveals diverse lipid profiles in inflammatory skin diseases like atopic dermatitis and psoriasis. This analysis highlights the potential of lipid metabolism studies for understanding and treating dermatologic conditions.
Area of Science:
- Dermatology and Lipidomics
- Investigates the intersection of skin health and lipid metabolism.
Background:
- Inflammatory skin conditions are often linked to disturbances in lipid metabolism.
- Understanding these connections is crucial for developing effective treatments.
Approach:
- Conducted a systematic review following PRISMA guidelines, searching for studies on lipidomics and skin/dermatology.
- Included 48 studies with 2651 participants, focusing on atopic dermatitis, acne, psoriasis, and hidradenitis suppurativa.
- Evaluated sampling techniques (Sebutape), analytical methods (LC-MS/MS), and statistical approaches (PCA, OPLS-DA).
Key Points:
- Sebutape emerged as a primary technique for in vivo skin lipidomics.
- Untargeted lipid profiling using liquid chromatography-tandem mass spectrometry was common.
- Significant heterogeneity in lipidomic profiles was observed across different skin diseases.
Conclusions:
- Skin lipidomic analysis offers valuable insights into the pathophysiology of dermatologic diseases.
- The findings suggest significant translational potential for diagnostic and therapeutic applications.
- Further research into skin lipid metabolism can advance dermatologic care.
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