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Pathological correlation between eosinophils and thyroid nodules based on medical image testing.

Mingjie He1, Tianqi Zhang2, Qing Huang3

  • 1Department of Endocrinology, Affiliated Hospital of Youjiang Medical University for Nationalities, No.18 Zhongshan Second Road, Youjiang District, Baise 533000, Guangxi, China; Department of Internal Medicine, Jinan University, No.601 West Huangpu Avenue, Tianhe District, Guangzhou 510000, Guangdong, China.

SLAS Technology
|September 20, 2024
PubMed
Summary
This summary is machine-generated.

This study links thyroid nodule (TN) pathology to eosinophils. Lower eosinophil levels and eosinophil-to-lymphocyte ratio (ELR) post-surgery may indicate thorough TN removal.

Keywords:
EosinophilsMedical image examinationPathological associationThyroid nodules

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Area of Science:

  • Endocrinology
  • Pathology
  • Medical Imaging

Background:

  • Thyroid nodules are common, but their pathology and pathogenesis require further investigation.
  • Medical imaging offers a valuable non-invasive approach to study thyroid nodule pathology.
  • Understanding the role of eosinophils in thyroid nodules is crucial for diagnosis and treatment.

Purpose of the Study:

  • To investigate eosinophil expression in medical imaging of thyroid nodules.
  • To explore the pathological correlation between eosinophils and thyroid nodules.
  • To assess the relationship between eosinophil counts, thyroid function, and surgical outcomes.

Main Methods:

  • Analysis of pathological reports and medical imaging data from thyroid nodule patients.
  • Collection and comparison of thyroid function tests (TT4, fT4, TSH) and leukocyte parameters.
  • Evaluation of eosinophil counts, percentages, and eosinophil-to-lymphocyte ratio (ELR) pre- and post-surgery.

Main Results:

  • Pre-surgery: Lower TT4 and fT4, higher TSH in the G2 group compared to G1.
  • Post-surgery: G1 group showed lower eosinophil counts, percentages, and ELR compared to G2 (p < 0.05).
  • Elevated TSH correlated with malignant thyroid nodules; lower ELR suggested complete nodule removal.

Conclusions:

  • Eosinophil levels and ELR may serve as potential biomarkers for thyroid nodule malignancy and surgical success.
  • Further research is needed to establish cut-off values for guiding diagnosis, treatment, and follow-up of thyroid nodules.
  • Medical imaging combined with hematological parameters offers insights into thyroid nodule pathology.