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Updated: Jun 30, 2026
Bacterial Detection & Identification Using Electrochemical Sensors
Published on: April 23, 2013
Ultrasensitive electrochemical detection of metronidazole using binder-free zinc-4,4'-oxybis(benzoic acid) MOF/GCE in
Chettipalayam Arunasalam Dhayanithi1, Sundaram Ganesh Babu2
1Nano-Catalysis Research Lab, Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore, 632014, Tamilnadu, India.
Abstract:
A novel electrochemical sensor is constructed by modifying the glassy carbon electrode (GCE) using a binder-free metal-organic framework of V-shaped linker 4,4'oxybis(benzoic acid) (OBA) and various transition metals (M-Zn, Mn, or Ni). The hydrothermally synthesized M-OBA MOFs demonstrated superior electron transfer ability and enhanced electro-reduction behaviour, making it highly effective for metronidazole (MTZ) detection. The optimized sensor demonstrated a linear response from 0.04 to 122.18 µM, a low detection limit (LOD) of 0.009 µM, and high sensitivity (0.48 µA µM-1 cm-2) using cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The sensor also exhibited excellent selectivity in the presence of various ions, organic compounds, and other antibiotics. The Zn-OBA MOF sensor proves practical applicability for detecting MTZ in milk, honey, tap water, and MTZ tablets.
