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The potential protective effect of 3-Hydroxybutyrate against aortic dissection: a mendelian randomization analysis
Shi Qiu1, Zhen Liu2, Chun-Ting Wang1
1Department of Cardiac Surgery, The Second Hospital of Shandong University, Jinan, Shandong, China.
Nutrition & Metabolism
|September 20, 2024
Summary
Genetically predicted 3-hydroxybutyrate (a ketone body) shows a protective effect against aortic dissection. This finding suggests a potential role for 3-hydroxybutyrate in cardiovascular health and disease prevention.
Area of Science:
- Cardiovascular Genetics
- Metabolic Research
Background:
- 3-Hydroxybutyrate, a key ketone body, is linked to cardiovascular benefits.
- The specific relationship between 3-hydroxybutyrate and aortic dissection risk is not well-established.
Purpose of the Study:
- To investigate the potential causal link between 3-hydroxybutyrate and aortic dissection.
- To leverage genetic data for a robust assessment of this relationship.
Main Methods:
- Utilized two-sample Mendelian randomization (MR) analysis with publicly available GWAS data.
- Examined 3-hydroxybutyrate, acetoacetate, and acetone as exposures for aortic dissection risk.
- Performed sensitivity analyses to ensure result validity.
Main Results:
- MR analysis revealed a significant inverse correlation between 3-hydroxybutyrate and aortic dissection risk (OR 0.147).
- Consistent protective effects were observed across multiple MR methods and after adjusting for other ketone bodies.
- No evidence of heterogeneity or pleiotropy was detected, supporting the findings.
Conclusions:
- Genetically predicted 3-hydroxybutyrate demonstrates a protective effect against aortic dissection.
- These findings highlight the potential role of 3-hydroxybutyrate in mitigating aortic dissection risk.
