Chitosan-Based Composite Aerogel with a Rapid Tissue Hydration Layer-Triggered Response to Promote Hemostasis
Kaiqiang Chen1, Wencheng Liang1, Jiakang Zhang2
1College of Chemical and Material Engineering, Quzhou University, Zhejiang 324000, P. R. China.
Biomacromolecules
|September 21, 2024
Summary
This study introduces a novel composite aerogel hemostatic material. The material demonstrates rapid tissue hydration layer-triggered properties for enhanced hemostasis and biocompatibility.
Area of Science:
- Biomaterials Science
- Materials Engineering
- Hemostatic Agents
Background:
- Aerogels have limited hemostatic properties due to poor adhesion to wet tissues.
- Developing effective hemostatic materials requires addressing the challenge of wet tissue interaction.
Purpose of the Study:
- To develop a novel aerogel hemostatic material with improved adhesion and efficacy.
- To investigate the 'rapid tissue hydration layer-triggered property' for enhanced hemostasis.
Main Methods:
- Fabrication of a composite aerogel hemostatic material (Bscai/Csde) using a chitosan derivative and Bletilla striata complex.
- Amide reaction to create a swollen chitosan derivative, followed by incorporation of Bletilla striata complex.
- Evaluation of the material's hemostatic ability, hemocompatibility, antibacterial properties, and cytocompatibility.
Main Results:
- The Bscai/Csde hemostatic material showed a rapid tissue hydration layer-triggered response.
- Demonstrated outstanding hemostasis ability, hemocompatibility, and antibacterial properties.
- Exhibited excellent cytocompatibility and a straightforward preparation method with readily available raw materials.
Conclusions:
- The developed Bscai/Csde composite aerogel is a promising hemostatic material.
- The 'rapid tissue hydration layer-triggered property' is a viable strategy for improving aerogel hemostats.
- This novel approach offers significant potential for future hemostatic applications.
Related Concept Videos
01:10Radical Chain-Growth Polymerization: Overview
Chain-growth or addition polymerization is successive addition reactions of monomers with a polymer chain. In radical chain-growth polymerization, the reaction proceeds via a free-radical intermediate. The free radical is formed from radical initiators, which spontaneously generate free radicals by homolytic fission. Organic peroxides (such as dibenzoyl peroxide, as shown in Figure 1) or azo compounds are popular radical initiators. A low concentration ratio of radical initiator to monomer is...
01:06Coagulation
Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...
01:22Formation of the Platelet Plug
The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
01:09Coagulation
The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
01:16Clot Retraction and Fibrinolysis
After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
01:27Fast Reactions
Fast reactions occurring in times shorter than the time needed to mix reactants pose a unique challenge for investigation. In a liquid-phase continuous-flow system, reactants A and B are swiftly pushed into the mixing chamber, where mixing occurs within 1 ms. The reaction mixture then flows through an observation tube, and one measures light absorption to determine species concentrations at various points of the tube. This method is most appropriate when relatively large volumes of reactants...