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Total nutritional support through the peritoneal cavity.

R B Gilsdorf, R R Selby, D A Schon

    Journal of the American College of Nutrition
    |January 1, 1985
    PubMed
    Summary
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    Peritoneal nutrient delivery in dogs showed promise, with significant nutrient infusion possible over 30 days. However, challenges like weight loss and circulatory collapse indicate total nutritional support feasibility requires further study.

    Area of Science:

    • Veterinary Medicine
    • Nutritional Science
    • Surgical Research

    Background:

    • Total nutritional support is crucial for recovery but often requires intravenous access.
    • Peritoneal dialysis demonstrates the potential for absorption through the peritoneal membrane.
    • Investigating alternative routes for nutritional delivery is essential for clinical applications.

    Purpose of the Study:

    • To evaluate the feasibility of delivering total nutritional support via the peritoneal cavity in dogs.
    • To assess the physiological impact and survival rates associated with 30-day intraperitoneal nutrient infusion.

    Main Methods:

    • Ten dogs received continuous intraperitoneal infusion of a nutrient solution (1.5% amino acids, 10% glucose, 1% lipids) for 30 days.
    • Nutrient solution was administered at a rate of 4 ml/kg/hr.

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  • Clinical parameters, weight, and serum chemistries were monitored throughout the study.

    • Main Results:

    • Seven of ten dogs survived with a mean weight loss of 13.9%.
    • Serum albumin decreased significantly, but other chemistries remained largely stable.
    • Peritoneal inflammation was observed initially but resolved by study completion.
    • Three dogs experienced fatal circulatory collapse within the first week.

    Conclusions:

    • Significant nutrient volumes can be delivered intraperitoneally.
    • While feasible for partial support, the study did not confirm the viability of total nutritional support via this route.
    • Further research is needed to overcome complications like weight loss and circulatory collapse for successful total nutritional support.