Related Experiment Video
Updated: Jun 12, 2025

13:19
Quantifying Antibody-Dependent Cellular Cytotoxicity in a Tumor Spheroid Model: Application for Drug Discovery
Published on: April 26, 2024
2.6K
Breast cancer immunotherapy: Realities and advances
Aixa Medina1,2, Jeismar Carballo1, Eglys González-Marcano1
1Jacinto Convit World Organization Inc. Pompano Beach Florida USA.
Cancer Innovation
|September 23, 2024
Summary
Breast cancer immunotherapy shows promise but faces challenges. This review summarizes recent advances, ongoing trials, and approved therapies for breast cancer (BC) treatment.
Area of Science:
- Oncology
- Immunology
Background:
- Breast cancer (BC) is a leading cause of cancer death in women globally.
- Advances in immunology have spurred the development of novel immunotherapies for BC.
- Current immunotherapies face challenges including resistance and modest response rates.
Purpose of the Study:
- To summarize recent data on breast cancer immunotherapy.
- To review ongoing clinical trials and approved therapies.
- To assess immunotherapy as monotherapy or in combination with conventional treatments.
Main Methods:
- Literature review of recent studies on breast cancer immunotherapy.
- Analysis of data from ongoing clinical trials.
- Evaluation of approved immunotherapeutic agents.
Main Results:
- Immunotherapy offers a promising approach for BC treatment.
- Various strategies including nonspecific immunotherapies, monoclonal antibodies, vaccines, and oncolytic viruses are being explored.
- Combination therapies and monotherapies are under investigation.
Conclusions:
- Immunotherapy is a rapidly evolving field for breast cancer treatment.
- Further research and clinical trials are necessary to overcome resistance and improve response rates.
- Personalized approaches may enhance the efficacy of breast cancer immunotherapy.
Related Concept Videos
Tumor Immunotherapy
491
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
491
Cancer Vaccines
345
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
345
Cancer Therapies
7.6K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.6K
Targeted Cancer Therapies
7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.5K
Cancer Survival Analysis
331
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
331
Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K

