Related Experiment Video
Updated: May 12, 2026

Evaluation of a Novel Laser-assisted Coronary Anastomotic Connector - the Trinity Clip - in a Porcine Off-pump Bypass Model
Published on: November 24, 2014
Dissection and Re-entry Techniques for Chronic Total Occlusion Percutaneous Coronary Intervention
Reza Masoomi1, Marouane Boukhris2, Silvia Moscardelli1,3
1Division of Cardiology, University of Washington Seattle, WA, US.
Insights
New dissection/re-entry techniques improve success rates for percutaneous coronary intervention in complex chronic total occlusions. These methods, including antegrade and retrograde approaches, are vital for treating challenging arterial blockages.
Area of Science:
- Interventional Cardiology
- Vascular Surgery
Background:
- Percutaneous coronary intervention (PCI) for chronic total occlusion (CTO) initially faced limited success rates with traditional methods.
- Advancements in dissection/re-entry techniques and retrograde approaches have expanded treatment options for complex CTOs.
Purpose of the Study:
- To review contemporary antegrade and retrograde dissection re-entry techniques for CTO.
- To evaluate the acute and longer-term outcomes of these advanced PCI methods.
Main Methods:
- Review of current literature on antegrade and retrograde dissection re-entry techniques for CTO.
- Analysis of angiographic characteristics influencing technique selection (e.g., lesion length, tortuosity, calcification, proximal cap ambiguity).
- Focus on the utilization of the extraplaque space for safe and effective recanalization.
Main Results:
- Dissection/re-entry techniques are crucial for complex CTOs, particularly those with long, tortuous, calcified lesions or ambiguous proximal caps.
- Both antegrade and retrograde approaches utilizing the extraplaque space are fundamental for successful CTO recanalization.
- These techniques have improved outcomes in challenging CTO cases.
Conclusions:
- Contemporary antegrade and retrograde dissection re-entry techniques represent significant advancements in CTO treatment.
- Mastery of the extraplaque space is essential for achieving high success rates in complex CTO PCI.
- These techniques offer improved acute and long-term outcomes for patients with CTO.
Abstract:
Despite early stagnation in success rates for percutaneous coronary intervention for chronic total occlusion with the traditional antegrade wiring approach, the introduction of dissection/re-entry techniques and the retrograde approach opened new avenues for operators to tackle more complex occlusions. Dissection/re-entry techniques (both antegrade and retrograde) are commonly used in angiographic scenarios characterised by long, tortuous and calcified occlusions, as well as in those with proximal cap ambiguity. Familiarity and comfort using the extraplaque space (with either an antegrade or retrograde approach) have become fundamental to achieving safe and effective recanalisation of complex chronic total occlusions. This review provides an overview of different contemporary antegrade and retrograde dissection re-entry techniques and their acute and longer-term outcomes.
Related Concept Videos
Cardiac Catheterization I: Pre-Procedure Overview
Cardiac Catheterization III: Left Heart Catheterization
Coronary Artery Disease V: Interprofessional Care
Peripheral Artery Disease III: Interprofessional Care

