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Insights into therapeutic peptides in the cancer-immunity cycle: Update and challenges

Xiaokun Zhang1, Ye Wu1, Jiayi Lin1

  • 1Shanghai Frontiers Science Center for Chinese Medicine Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research and Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.

Acta Pharmaceutica Sinica. B
|September 23, 2024
PubMed

Insights

Therapeutic peptides show promise for enhancing cancer immunotherapies (CITs) by targeting the cancer-immunity cycle (CIC). Challenges in peptide stability and conformation are being addressed for improved clinical efficacy and safety.

Area of Science:

  • Oncology
  • Immunology
  • Peptide Therapeutics

Background:

  • Immunotherapies offer durable potency and long-term survival in cancer treatment.
  • Therapeutic peptides, with high tissue penetration and selectivity, can enhance cancer immunotherapies (CITs).
  • Peptide conformation and stability present challenges to on-target efficacy in cancer therapy.

Purpose of the Study:

  • To provide a comprehensive overview of therapeutic peptides targeting the cancer-immunity cycle (CIC).
  • To discuss opportunities and challenges of peptides in boosting CIC within clinical progress.
  • To explore future developments in peptide-based CITs for robust efficacy and safety.

Main Methods:

  • Review of recent advancements in therapeutic peptides.
  • Analysis of peptides targeting tumor antigen presentation, immune cell regulation, and immune checkpoint signaling.
  • Examination of clinical progress and future directions in peptide-based cancer immunotherapy.

Main Results:

  • Therapeutic peptides are being developed to target key steps of the cancer-immunity cycle.
  • Opportunities exist for peptides to enhance antigen presentation and immune cell regulation.
  • Challenges related to peptide physicochemical properties are being investigated for improved CITs.

Conclusions:

  • Therapeutic peptides hold significant promise for advancing cancer immunotherapy.
  • Addressing peptide stability and conformation is crucial for clinical success.
  • Future research will focus on developing novel peptide-based CITs with enhanced efficacy and safety profiles.
Keywords:
Cancer immunotherapyCancer-immunity cycleImmune checkpoint blockadeOncolytic peptidePeptide mimotopePeptide neoantigen vaccinePeptide-major histocompatibility complexSynthetic long peptide vaccine

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