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Ethylene oxide graft copolymers reduce the immunogenicity of lipid nanoparticles
Yalin Qi1,2, Hesong Han1,2, Albert Liu1,2
1Department of Bioengineering, University of California, Berkeley Berkeley California 94720 USA nmurthy@berkeley.edu.
RSC Advances
|September 23, 2024
Abstract:
Lipid nanoparticle (LNP)/mRNA complexes have great therapeutic potential but their PEG chains can induce the production of anti-PEG antibodies. New LNPs that do not contain PEG are greatly needed. We demonstrate here that poly-glutamic acid-ethylene oxide graft copolymers can replace the PEG on LNPs and outperform PEG-LNPs after chronic administration.
