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A safe method for rapid therapeutic pancreatic cooling
Megan Summers1, Benjamin Russell1, Prasad Rajalingamgari1
1Department of Medicine, Mayo Clinic, Scottsdale, AZ, USA.
Iscience
|September 23, 2024
Summary
This study shows rapid transgastric pancreatic cooling is safe in large animals resembling humans. This method may offer a new targeted therapy for acute pancreatitis (AP).
Area of Science:
- Gastroenterology
- Surgical Innovation
- Therapeutic Hypothermia
Background:
- Acute pancreatitis (AP) lacks targeted treatment options.
- Previous studies in rats showed pancreatic cooling ameliorated AP.
- Yucatan pigs, with human-like anatomy, were used to model AP treatment.
Purpose of the Study:
- To assess the safety and efficacy of transgastric pancreatic cooling in large animals.
- To determine if endoscopic cooling is feasible in pigs with human-like anatomy.
- To establish a preclinical model for AP therapeutic hypothermia.
Main Methods:
- Endoscopic placement of a gastric cooling balloon in Yucatan pigs.
- Monitoring of pancreatic and bladder temperatures using wireless transmitters.
- Comparison of different water perfusion temperatures and control groups (sedation only, un-perfused balloons).
Main Results:
- Transgastric pancreatic cooling to ≤32°C or ≤26°C was achieved within 90 minutes using ≤19°C or ≤10°C water, respectively.
- Cooling was well-tolerated for one month without sedation.
- No significant differences in bladder temperature, behavior, or biomarkers were observed between groups.
Conclusions:
- Rapid transgastric pancreatic cooling is safely achievable in large animals with relevant anatomy.
- This technique shows promise as a potential targeted therapy for acute pancreatitis.
- Further clinical studies are warranted to evaluate this approach in human patients.
