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Updated: Jun 12, 2025

Isolating Free Carbenes, their Mixed Dimers and Organic Radicals
Published on: April 19, 2019
Catalyst-Free Radical Carbosulfonylation of Enamides with Indoles, Aryldiazonium Tetrafluoroborates, and DABCO·(SO2)2
Changmei Zhang1, Hao Cheng2, Yuanyuan An3
1School of Pharmaceutical and Materials Engineering & Institute for Advanced Studies, Taizhou University, 1139 Shifu Avenue, Taizhou 318000, China.
Abstract:
Herein, we have developed a catalyst-free four-component carbosulfonylation of enamides involving indoles, DABCO·(SO2)2, and aryldiazonium tetrafluoroborates for the preparation of various β-amidosulfone products in moderate to excellent yields. This approach features mild reaction conditions, high step-efficiency, and broad substrate scope, which provides a green and efficient strategy for carbosulfonyl difunctionalization of enamides. Based on the results of mechanism studies, a radical tandem reaction process is proposed for the transformation.
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