Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Analysis of Population Pharmacokinetic Data01:12

Analysis of Population Pharmacokinetic Data

239
Analysis of population pharmacokinetic data involves studying the behavior of drugs within diverse populations to understand their pharmacokinetic parameters. Traditional pharmacokinetic methods typically involve collecting samples from a few individuals and estimating these parameters. While these methods are commonly used, they have limitations in capturing the variability in drug response among individuals or heterogeneous populations. Population pharmacokinetics is employed to address these...
239
Model Approaches for Pharmacokinetic Data: Distributed Parameter Models01:06

Model Approaches for Pharmacokinetic Data: Distributed Parameter Models

64
Pharmacokinetic models are mathematical constructs that represent and predict the time course of drug concentrations in the body, providing meaningful pharmacokinetic parameters. These models are categorized into compartment, physiological, and distributed parameter models.
The distributed parameter models are specifically designed to account for variations and differences in some drug classes. This model is particularly useful for assessing regional concentrations of anticancer or...
64
Drug Therapy01:28

Drug Therapy

39
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
39
Model Approaches for Pharmacokinetic Data: Compartment Models01:14

Model Approaches for Pharmacokinetic Data: Compartment Models

83
Compartmental analysis is a widely adopted approach to characterizing drug pharmacokinetics. It uses compartment models that conceptualize the body as a collection of reversibly communicating compartments, each representing a group of tissues exhibiting similar drug distribution characteristics. The movement rate of the drug between these compartments is typically described by first-order kinetics.
Two primary types of compartment models are recognized: mammillary and catenary. The more...
83
Model-Independent Approaches for Pharmacokinetic Data: Noncompartmental Analysis00:59

Model-Independent Approaches for Pharmacokinetic Data: Noncompartmental Analysis

51
Noncompartmental analyses offer an alternative method for describing drug pharmacokinetics without relying on a specific compartmental model. In this approach, the drug's pharmacokinetics are assumed to be linear, with the terminal phase log-linear. This assumption allows for simplified analysis and interpretation of the drug's behavior in the body.
One important characteristic of noncompartmental analyses is that drug exposure increases proportionally with increasing doses. This...
51
Nonlinear Pharmacokinetics: Overview01:19

Nonlinear Pharmacokinetics: Overview

309
Nonlinear or dose-dependent pharmacokinetics is a phenomenon that occurs when the pharmacokinetic parameters of certain drugs deviate from linear pharmacokinetics at higher doses. These drugs do not follow the expected first-order kinetics, where the rate of drug elimination is directly proportional to the drug concentration. Instead, they exhibit a nonlinear relationship, which can be attributed to several factors.
Nonlinearity can arise due to the saturation of plasma protein-binding or...
309

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of Part D Senior Savings Model on healthcare costs among the Medicare population.

Journal of pharmaceutical health services research : an official journal of the Royal Pharmaceutical Society of Great Britain·2025
Same author

Effects of the Part D Senior Savings Model on racial and ethnic disparities in healthcare costs.

Current medical research and opinion·2025
Same author

Cost-effectiveness of medication therapy management among Medicare population and across racial/ethnic groups.

Medicine·2024
Same author

Effects of comprehensive medication review on opioid overuse among medicare beneficiaries.

Journal of pharmaceutical health services research : an official journal of the Royal Pharmaceutical Society of Great Britain·2024
Same author

Racial and ethnic disparities in the enrolment of medicare medication therapy management programs.

Journal of pharmaceutical health services research : an official journal of the Royal Pharmaceutical Society of Great Britain·2023
Same author

Disparities associated with Medicare Part D Star Ratings measures among patients with Alzheimer's disease and related dementias.

Medicine·2023

Related Experiment Video

Updated: Jun 12, 2025

Author Spotlight: Generating Neuronal Phenotypic Profiles - A Protocol to Culture and Image Human Midbrain Dopaminergic Neurons
09:21

Author Spotlight: Generating Neuronal Phenotypic Profiles - A Protocol to Culture and Image Human Midbrain Dopaminergic Neurons

Published on: July 7, 2023

1.5K

Enhancing pharmacist intervention targeting based on patient clustering with unsupervised machine learning.

Chi Chun Steve Tsang1, Junling Wang1

  • 1Department of Clinical Pharmacy and Translational Science, University of Tennessee Health Science Center College of Pharmacy, Memphis, TN, USA.

Expert Review of Pharmacoeconomics & Outcomes Research
|September 23, 2024
PubMed
Summary

Pharmacists can identify patients needing diabetes care interventions. Machine learning identified specific patient groups, including publicly insured elderly and privately insured middle-aged females, for targeted support to improve adherence to American Diabetes Association standards.

Keywords:
Adherencediabetespatient clusterpharmaciststandard of careunsupervised machine learning

More Related Videos

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

7.5K
Predicting Treatment Response to Image-Guided Therapies Using Machine Learning: An Example for Trans-Arterial Treatment of Hepatocellular Carcinoma
04:09

Predicting Treatment Response to Image-Guided Therapies Using Machine Learning: An Example for Trans-Arterial Treatment of Hepatocellular Carcinoma

Published on: October 10, 2018

8.2K

Related Experiment Videos

Last Updated: Jun 12, 2025

Author Spotlight: Generating Neuronal Phenotypic Profiles - A Protocol to Culture and Image Human Midbrain Dopaminergic Neurons
09:21

Author Spotlight: Generating Neuronal Phenotypic Profiles - A Protocol to Culture and Image Human Midbrain Dopaminergic Neurons

Published on: July 7, 2023

1.5K
A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

7.5K
Predicting Treatment Response to Image-Guided Therapies Using Machine Learning: An Example for Trans-Arterial Treatment of Hepatocellular Carcinoma
04:09

Predicting Treatment Response to Image-Guided Therapies Using Machine Learning: An Example for Trans-Arterial Treatment of Hepatocellular Carcinoma

Published on: October 10, 2018

8.2K

Area of Science:

  • Diabetes Management
  • Health Services Research
  • Machine Learning in Healthcare

Background:

  • Adherence to the American Diabetes Association (ADA) Standards of Medical Care is suboptimal.
  • Effective identification of patients for diabetes interventions is crucial for improving health outcomes.

Purpose of the Study:

  • To assist pharmacists in identifying patients for diabetes control interventions.
  • To apply unsupervised machine learning for patient stratification in diabetes care.

Main Methods:

  • Analysis of the 2021 Medical Expenditure Panel Survey data.
  • Utilized k-mode cluster analysis on patient features including preventive care adherence and demographics.
  • Included adherence to HbA1c tests, foot exams, cholesterol tests, eye exams, and flu vaccination.

Main Results:

  • Included 1,219 patients with self-reported diabetes; overall adherence to ADA standards was 33.72%.
  • Identified five patient clusters based on complexity, insurance, and demographics.
  • Clusters B (moderate-complexity, publicly insured female), C (low-complexity, privately insured female), and E (moderate-complexity, publicly insured male) showed nonadherence.

Conclusions:

  • Pharmacists can target specific patient groups for diabetes interventions.
  • Publicly insured elderly (Groups B and E) and privately insured middle-aged females (Group C) are key targets.
  • Interventions can include resource navigation and reminders to improve diabetes care adherence.