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Blocking Tryptophan Catabolism Reduces Triple-Negative Breast Cancer Invasive Capacity
Li-Wei Kuo1,2, Lyndsey S Crump2, Kathleen O'Neill2
1Cancer Biology Training Program, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Cancer Research Communications
|September 23, 2024
Abstract
Significance:
TDO2 is more highly expressed than the nonhomologous TRP-catabolizing enzyme IDO1 in TNBC. We find that TDO2 knockdown can lead to a compensatory increase in IDO1. Therefore, we tested a newly developed TDO2/IDO1 dual inhibitor and found that it decreases TRP catabolism, anchorage-independent survival, and invasive capacity.

