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Case Report: Adult Onset Still Disease in a 26-year-old Male
Tayler Modlin1, Bailey Pickering1, Kaihlen Smith1
1University of South Dakota Sanford School of Medicine.
Summary
Adult onset Still's disease (AOSD) is a rare inflammatory condition. Early diagnosis and treatment with corticosteroids and Canakinumab can lead to symptom resolution in affected patients.
Area of Science:
- Rheumatology
- Internal Medicine
- Systemic Inflammatory Diseases
Background:
- Adult onset Still's disease (AOSD) is a rare systemic inflammatory disorder of unknown cause.
- Diagnosis can be challenging due to its nature as a diagnosis of exclusion.
- Key clinical features include fever, rash, arthralgia/arthritis, and sore throat.
Observation:
- A 26-year-old male presented with fever, generalized pain, and a salmon-colored rash.
- Physical examination revealed abdominal tenderness, hepatomegaly, joint pain, and a maculopapular rash.
- Laboratory findings included leukocytosis, elevated ESR, haptoglobin, and CRP.
Findings:
- The patient met the diagnostic criteria for Adult onset Still's disease (AOSD).
- Initial treatment with high-dose prednisone resulted in a positive response.
- Subsequent treatment with Canakinumab led to sustained symptom remission.
Implications:
- This case highlights the importance of considering AOSD in patients with characteristic symptoms.
- Effective management involves prompt diagnosis and targeted therapies such as corticosteroids and biologics.
- Canakinumab offers a potential therapeutic option for managing AOSD and preventing relapses.
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