Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hydrogen Bonding Polarization Strengthening the Peptide-Based Hydrogels.

The journal of physical chemistry. B·2024
Same author

Advances in Ophthalmic Optogenetics: Approaches and Applications.

Biomolecules·2022
Same author

A Scoping Review of Drug Epidemic Models.

International journal of environmental research and public health·2022
Same author

Evaluation of reconstructed auricles by convolutional neural networks.

Journal of plastic, reconstructive & aesthetic surgery : JPRAS·2022
Same author

Facial expression recognition based on deep learning.

Computer methods and programs in biomedicine·2022
Same author

Glucagon-Like Peptide-1 Receptor Regulates Macrophage Migration in Monosodium Urate-Induced Peritoneal Inflammation.

Frontiers in immunology·2022

Related Experiment Video

Updated: Jun 24, 2026

Sensing of Barrier Tissue Disruption with an Organic Electrochemical Transistor
11:17

Sensing of Barrier Tissue Disruption with an Organic Electrochemical Transistor

Published on: February 10, 2014

11.7K

Operando Decoding Ion-Conductive Switch in Stimuli-Responsive Hydrogel by Nanodiamond-Based Quantum Sensing.

Ruqiang Dou1,2, Zan Li2, Guoli Zhu2

  • 1Research Institute of Interdisciplinary Sciences & School of Materials Science and Engineering, Dongguan University of Technology, Dongguan, 523808, China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|September 23, 2024
PubMed
Summary

Researchers developed thermal-responsive hydrogels as switches for energy storage. Nanodiamond quantum sensing revealed that microscopic phase separation physically blocks ion conduction at high temperatures, explaining the switch-off mechanism.

Keywords:
HydrogelPNIPAM‐AMnanodiamondquantum sensingsol‐gel transition

More Related Videos

Silicon Metal-oxide-semiconductor Quantum Dots for Single-electron Pumping
14:58

Silicon Metal-oxide-semiconductor Quantum Dots for Single-electron Pumping

Published on: June 3, 2015

14.6K
Author Spotlight: High-Quality Quantum Dot Nanobeads for Sensitive Fluorescent Lateral Flow Immunoassays
07:13

Author Spotlight: High-Quality Quantum Dot Nanobeads for Sensitive Fluorescent Lateral Flow Immunoassays

Published on: June 28, 2024

1.2K

Related Experiment Videos

Last Updated: Jun 24, 2026

Sensing of Barrier Tissue Disruption with an Organic Electrochemical Transistor
11:17

Sensing of Barrier Tissue Disruption with an Organic Electrochemical Transistor

Published on: February 10, 2014

11.7K
Silicon Metal-oxide-semiconductor Quantum Dots for Single-electron Pumping
14:58

Silicon Metal-oxide-semiconductor Quantum Dots for Single-electron Pumping

Published on: June 3, 2015

14.6K
Author Spotlight: High-Quality Quantum Dot Nanobeads for Sensitive Fluorescent Lateral Flow Immunoassays
07:13

Author Spotlight: High-Quality Quantum Dot Nanobeads for Sensitive Fluorescent Lateral Flow Immunoassays

Published on: June 28, 2024

1.2K

Area of Science:

  • Materials Science
  • Polymer Chemistry
  • Nanotechnology

Background:

  • Thermal-responsive hydrogels are promising for energy storage devices due to their ion-conductive switching capabilities.
  • The precise molecular mechanism behind the on/off switching behavior of these hydrogels remains poorly understood.

Purpose of the Study:

  • To investigate the molecular mechanism of ion conduction switching in thermal-responsive hydrogels.
  • To elucidate the role of phase separation and nanoscale properties in hydrogel ion transport.

Main Methods:

  • Synthesis of poly(N-isopropylacrylamide-co-acrylamide) hydrogel as a model system.
  • In situ visualization of micro-scale phase separation and cross-linked mesh structure.
  • Nanodiamond (ND) based quantum sensing to probe nanoscale viscosity, thermal conductivity, and ionic mobility.

Main Results:

  • Micro-scale phase separation and a "chemically frozen" state of water molecules were observed during sol-gel transition.
  • Nanoscale inhomogeneities in viscosity, thermal conductivity, and ionic mobility were detected using ND quantum sensing.
  • Ionic mobility was found to be dependent on both temperature and polymer concentration.

Conclusions:

  • Inhomogeneous phase separation at the microscale creates physical barriers that impede ion conduction pathways.
  • This physical blocking mechanism provides a potential intrinsic explanation for the shutdown of ion migration in ionic hydrogels at elevated temperatures.