[Effect of various infusion media and solutions on the kallikrein-kinin system of human plasma]
Related Experiment Video
Updated: Sep 29, 2026

Hydrogel Nanoparticle Harvesting of Plasma or Urine for Detecting Low Abundance Proteins
Published on: August 7, 2014
Abstract:
Activities of prekallikrein and Hageman factor (factor XII) were studied in some natural and artificial infusion media: polyglukine, rheoglumane, gemodes, polypher, gelatinol, saline; in solutions for parenteral nutrition--hydrolysate of casein, aminopeptide, aminokrovine, glucose solutions as well as in 10% NaCl and novocain. All the solutions studied did not affect the purified preparations of prekallikrein, but some of them activated partially purified preparations of Hageman factor. However, all these solutions, except of Ringer solution, activated Hageman factor and prekallikrein in human blood serum. Activation of prekallikrein appears to occur via the active form of Hageman factor. Among the solutions studied casein hydrolysate, 5% glucose, gelatinol and novocain exhibited the highest stimulating effect on Hageman factor and prekallikrein. Possible mechanisms of the activation are discussed.
Related Concept Videos
Anticoagulant Drugs: Low-Molecular-Weight Heparins
One-Compartment Model: IV Infusion
The one-compartment model for IV infusion uses mathematical equations to describe the rate of change in drug quantity in the body. At steady-state or infusion equilibrium, the drug input...
Acute Kidney Injury IV: Diagnostic Studies and Prevention
Acute Kidney Injury V: Interprofessional Care
Acute Inflammation III: Local and Systemic Effects

