Fast Attentional Information Routing via High-Frequency Bursts in the Human Brain

Brain-wide communication supporting flexible behavior requires coordination between sensory and associative regions but how brain networks route sensory information at fast timescales to guide action remains unclear. Using spiking neural networks and human intracranial electrophysiology during spatial attention tasks, where participants detected targets at cued locations, we show that high-frequency activity bursts (HFAb) serve as information-carrying events, facilitating fast, long-range communications. HFAbs were evoked by sensory cues and targets, dynamically linked to low-frequency rhythms. Notably, both HFAb responses following cues and their decoupling from slow rhythms predicted performance accuracy. HFAbs were synchronized at the network-level, identifying distinct cue- and target-activated subnetworks. These subnetworks exhibited a temporal lead-lag organization following target onset, with cue-sactivated subnetworks preceding target-activated subnetworks when the cue provided relevant target information. Computational modeling indicated that HFAbs reflect transitions to coherent population spiking and are coordinated across networks through distinct mechanisms. Together, these findings establish HFAbs as neural mechanisms for fast, large-scale communication supporting attentional performance.